Question 1

Figure 20.4
 
-The structures of the influenza drug Tamiflu and sialic acid, the substrate for influenza virus's neuramidase, are shown in Figure 20.4. What is the method of action of Tamiflu?

Accepted Answer

A)   prevents synthesis of virus spikes
B)   inhibits cell wall synthesis
C)   competitive inhibition
D)   inhibits plasma membrane synthesis
E)   inhibits synthesis of neuramidaseF) B) and D)
G) C) and D)

Question 2

Which of the following antibiotics are used to treat fungal infections? 1. aminoglycosides
2)  cephalosporins
3)  griseofulvin
4)  polyenes
5)  bacitracin

Accepted Answer

A)   1, 2, and 3
B)   3 and 4
C)   3, 4, and 5
D)   4 and 5
E)   All of these antibiotics are used to treat fungal infections.F) A) and E)
G) B) and D)

Question 3

Use of antibiotics in animal feed leads to antibiotic- resistant bacteria because

Accepted Answer

A)   bacteria from other animals replace those killed by the antibiotics.
B)   the antibiotics persist in soil and water.
C)   the few surviving bacteria that are affected by the antibiotics develop immunity to the antibiotics, which they pass on to their progeny.
D)   the antibiotics cause new mutations to occur in the surviving bacteria, which results in resistance to antibiotics.
E)   the antibiotics kill susceptible bacteria, but the few that are naturally resistant live and reproduce, and their progeny repopulate the host animal.F) C) and D)
G) A) and E)

Question 4

Antimicrobial peptides work by

Accepted Answer

A)   disrupting the plasma membrane.
B)   complementary base pairing with DNA.
C)   hydrolyzing peptidoglycan.
D)   inhibiting cell- wall synthesis.
E)   inhibiting protein synthesis.F) A) and B)
G) B) and D)

Question 5

Which of the following would be selective against the tubercle bacillus?

Accepted Answer

A)   ethambutol - inhibits mycolic acid synthesis
B)   streptomycin - inhibits protein synthesis
C)   bacitracin - inhibits peptidoglycan synthesis
D)   vancomycin - inhibits peptidoglycan synthesis
E)   streptogramin - inhibits protein synthesisF) A) and B)
G) C) and E)

Question 6

Phage therapy has been used in the past as an antiviral treatment.

Accepted Answer

A) True 
 B)False

Question 7

Which of the following antibiotics causes misreading of mRNA?

Accepted Answer

A)   chloramphenicol - inhibits peptide bonds at 50S subunit
B)   oxazolidinone - prevents formation of 70S ribosome
C)   aminoglycoside - changes shape of 30S units
D)   streptogamin - prevents release of peptide from 70S ribosome
E)   tetracyclines - bind with 30S subunitF) A) and D)
G) None of the above

Question 8

Both trimethoprim and sulfamethoxazole inhibit reactions along the same metabolic pathway.

Accepted Answer

A) True 
 B)False

Question 9

Table 20.2
The following results were obtained from a disk- diffusion test for microbial susceptibility to antibiotics. Staphylococcus aureus was the test organism.  \begin{array}{c}\begin{array}{lll} \text {Antibiotic}\ \text {B  7 \mathrm{~mm} }\ \text {C $ 0 \mathrm{~mm} $ }\ \text {D $ 10 \mathrm{~mm} $ }\end{array}\begin{array}{lll}\text { Zone of Inhibition A } \\\\\end{array}\begin{array}{lll}3 \mathrm{~mm} \\\\\end{array}\end{array}

-In Table 20.2, the most effective antibiotic tested was

Accepted Answer

A)   A.
B)   B.
C)   C.
D)   D.
E)   The answer cannot be determined based on the information provided. F) A) and B)
G) B) and E)

Question 10

An antibiotic that attacks the LPS layer would be expected to have a narrow spectrum of activity.

Accepted Answer

A) True 
 B)False

Question 11

Figure 20.2
 
-The antibiotic cycloheximide binds to the 60S subunit of the ribosome, as shown in Figure 20.2. The effect is to

Accepted Answer

A)   prevent peptide bond formation in prokaryotes.
B)   prevent mRNA-ribosome binding in eukaryotes.
C)   prevent ribosome formation in bacteria.
D)   prevent transcription in prokaryotes.
E)   prevent polypeptide elongation in eukaryotes.F) B) and D)
G) A) and E)

Question 12

Which of the following methods of action would be bacteriostatic?

Accepted Answer

A)   competitive inhibition with folic acid synthesis
B)   competitive inhibition with DNA gyrase
C)   inhibition of protein synthesis
D)   injury to plasma membrane
E)   inhibition of cell wall synthesisF) A) and B)
G) A) and D)

Question 13

Which of the following is mismatched?

Accepted Answer

A)   Florey and Chain - identification of Penicillium as the producer of penicillin
B)   Fleming - identification of penicillin
C)   Ehrlich - "magic bullet" theory
D)   Kirby and Bauer - disc- diffusion method
E)   None of these is mismatched.F) A) and D)
G) A) and C)

Question 14

Niclosamide prevents ATP generation in mitochondria. You would expect this drug to be effective against

Accepted Answer

A)   Mycobacterium tuberculosis.
B)   gram- negative bacteria.
C)   gram- positive bacteria.
D)   viruses.
E)   helminths.F) B) and C)
G) A) and B)

Question 15

Which one of the following does NOT belong with the others?

Accepted Answer

A)   monobactam
B)   cephalosporin
C)   streptomycin
D)   bacitracin
E)   penicillinF) A) and D)
G) All of the above

Exam 20: Antimicrobial Drugs

An antibiotic that attacks the LPS layer would be expected to have a narrow spectrum of activity.

Correct Answer
verified

Use of antibiotics in animal feed leads to antibiotic- resistant bacteria because

Correct Answer
verified

Which of the following antibiotics are used to treat fungal infections? 1. aminoglycosides 2) cephalosporins 3) griseofulvin 4) polyenes 5) bacitracin

Correct Answer
verified

Which of the following would be selective against the tubercle bacillus?

Correct Answer
verified

Phage therapy has been used in the past as an antiviral treatment.

Correct Answer
verified

Figure 20.4 -The structures of the influenza drug Tamiflu and sialic acid, the substrate for influenza virus's neuramidase, are shown in Figure 20.4. What is the method of action of Tamiflu?

Correct Answer
verified

Which one of the following does NOT belong with the others?

Correct Answer
verified

Both trimethoprim and sulfamethoxazole inhibit reactions along the same metabolic pathway.

Correct Answer
verified

Which of the following methods of action would be bacteriostatic?

Correct Answer
verified

Figure 20.2 -The antibiotic cycloheximide binds to the 60S subunit of the ribosome, as shown in Figure 20.2. The effect is to

Correct Answer
verified

Niclosamide prevents ATP generation in mitochondria. You would expect this drug to be effective against

Correct Answer
verified

Which of the following is mismatched?

Correct Answer
verified

Which of the following antibiotics causes misreading of mRNA?

Correct Answer
verified

Correct Answer
verified

Antimicrobial peptides work by

Correct Answer
verified

Exam 20: Antimicrobial Drugs

An antibiotic that attacks the LPS layer would be expected to have a narrow spectrum of activity.

Correct AnswerverifiedShow Answer

Use of antibiotics in animal feed leads to antibiotic- resistant bacteria because

Correct AnswerverifiedShow Answer

Which of the following antibiotics are used to treat fungal infections? 1. aminoglycosides 2) cephalosporins 3) griseofulvin 4) polyenes 5) bacitracin

Correct AnswerverifiedShow Answer

Which of the following would be selective against the tubercle bacillus?

Correct AnswerverifiedShow Answer

Phage therapy has been used in the past as an antiviral treatment.

Correct AnswerverifiedShow Answer

Figure 20.4 -The structures of the influenza drug Tamiflu and sialic acid, the substrate for influenza virus's neuramidase, are shown in Figure 20.4. What is the method of action of Tamiflu?

Correct AnswerverifiedShow Answer

Which one of the following does NOT belong with the others?

Correct AnswerverifiedShow Answer

Both trimethoprim and sulfamethoxazole inhibit reactions along the same metabolic pathway.

Correct AnswerverifiedShow Answer

Which of the following methods of action would be bacteriostatic?

Correct AnswerverifiedShow Answer

Figure 20.2 -The antibiotic cycloheximide binds to the 60S subunit of the ribosome, as shown in Figure 20.2. The effect is to

Correct AnswerverifiedShow Answer

Niclosamide prevents ATP generation in mitochondria. You would expect this drug to be effective against

Correct AnswerverifiedShow Answer

Which of the following is mismatched?

Correct AnswerverifiedShow Answer

Which of the following antibiotics causes misreading of mRNA?

Correct AnswerverifiedShow Answer

Correct AnswerverifiedShow Answer

Antimicrobial peptides work by

Correct AnswerverifiedShow Answer

Correct Answer
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